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Diana Shi, MD

Principal Investigator

Diana Shi is an Assistant Professor in the Department of Radiation Oncology at Mass General Brigham and the Krantz Family Center for Cancer Research. She received her BA from Princeton University, her MD from Harvard Medical School, and her residency training from the Harvard Radiation Oncology Program. Her clinical and research focus is in IDH-mutant gliomas.

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    Jongchan Park, PhD

    Research Scientist

    Jongchan is originally from Seoul, South Korea, and received his Ph.D. from Yonsei University. His research focuses on understanding how IDH mutations in glioma alter the cellular environment, including epigenetic regulation, and how these changes influence therapeutic responses. He is particularly interested in leveraging these insights to identify potential therapeutic vulnerabilities in IDH-mutant glioma. Outside the lab, he enjoys traveling with his family, watching and playing baseball.

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    Akari Shiraishi, PhD

    Postdoctoral fellow

    Akari received her PhD from the University of Tokyo, where she investigated mechanisms of therapeutic resistance to molecular targeted therapies in cancer. In the Shi Lab, she is interested in understanding how oncometabolites influence protein function and contribute to cancer biology. Outside the lab, she enjoys traveling, exploring cafés and art museums, and discovering new places. Having been a member of her high school rowing team, she is looking forward to watching the Head of the Charles Regatta.

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    Alex Tsai, BA

    Research Technician

    Alex grew up in Holmdel, New Jersey and attended Princeton University where he majored in Molecular Biology. Alex has been working with Dr. Shi since graduating in 2023 and his research explores the genetic mechanisms behind vulnerabilities in IDH-mutant gliomas. Outside of the lab, Alex enjoys playing and watching tennis, playing the flute, hiking, and running. He is looking forward to running the Cambridge Half Marathon this year.

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    Christina Zheng, BA

    Research Technician

    Christina grew up in Medford, MA and earned a B.A. in Molecular Biology from Princeton University with a minor in Global Health and Health Policy. She is interested in metabolism, cancer biology, and translational research. Her current work investigates how targeted therapies influence IDH-mutant gliomas. Outside of the lab, she enjoys taking barre classes, figure skating, and playing basketball with her family.